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Benefits known from research

Sake prevents liver cancer: Statistical data in Japan indicate that the death rates due to cirrhosis liver (hardening) and liver
cancer are low in Tohoku district in Japan where the consumption rate of sake is the essence of sake, but no whisky and
brandy have such effect. Which chemical substances in sake are responsible to this is still a subject of research.

Most chemotherapy and radiotherapy kill both cancer cells and healthy cells. They also decrease lymphocytes, the natural
inhibitors of cancer cells. Better way of fighting against cancer is to activate NK cells or LAK cells. Professor Okada of Aichi
University, Japan, has found that sakekasu increases the effects of NK lymphocytes that kill cancer cells. More recent medical
research indicates that sake and sakekasu both include such substances that inhibit the cells of bladder cancer, prostrate
cancer and uterus cancer. The best part of sakekasu is that it is a food and has no medical side effects.

Stress reduction: Sake like other alcoholic beverages removes stress, promotes appetite, and improves human relations.

Sake increases good cholesterol: Cholesterol is a soft, waxy substance found among the lipids (fats) in the blood stream and in
all cells in the body. It is an important part of a healthy body because it is used to form cell membranes, some hormones and
other needed tissues. Cholesterol level is thought to be high if in the range between 200 and239, desirable if less than 200.

Low-density lipoprotein (LDL) is the major cholesterol carrier in the blood. When a person has too much LDL cholesterol
circulating in the blood, it can slowly build up within the walls of the arteries feeding the heart and brain. The formation of a clot
(or thrombus) in the region of this plaque can block the flow of blood to part of the heart muscle and cause a heart attack. If a
clot blocks the blood flow to the brain, the result is a stroke. A high level of LDL cholesterol reflects an increased risk of heart
disease. That is why LDL cholesterol is often called “bad” cholesterol. About one-third to one-fourth of blood cholesterol is
carried by high-density lipoprotein (HDL). HDL tends to carry cholesterol away from the arteries and back to the liver, where it’s
passed from the body. Some experts believe HDL removes excess cholesterol from atherosclerotic plaques and thus slows
their growth. HDL is known as “good” cholesterol because a high level of HDL seems to protect against heart attack.

Sake not only helps HDL cholesterol to remove LDL cholesterol accumulated in the blood vessels by transporting to liver and
decomposes, but also increases HDL cholesterol.

Body warming: Sake keeps body warm longer than other alcoholic beverages. It is found sake keeps body warm at a much
higher body temperature than whisky. The warmer temperature means a better blood circulation in the body, particularly in

Expansion of blood vessels for better blood circulation: As one gets older, the blood vessels become hardened and easily
clogged. As a consequence, blood circulation in capillaries is hindered. Sake stimulates heart and, at the same time, expands
blood vessels to assist smooth circulation. Sake also increases urokinase, and decreases trokisanchin-A2 that helps coagulate

Diabetes: The sugar in the blood is converted to fat by insulin. There are two kinds of diabetes; one is due to an insufficient
amount of insulin supplied, and another insufficient work of insulin. Therefore, the sugar level of the blood in the diabetes
patient increases. The sugar that is not absorbed in fat is discharged to urine.

The body has the hormones that have opposite effects of insulin, including growth hormone, and catecholamine.
Catecholamine is a hormone that includes adrenaline. Adrenaline decomposes body fat and increases sugar in the blood that is
opposite to insulin. The current therapy for diabetes is either to increase insulin in the body by direct injection or to suppress
the work of catecholamine. Sakekasu contains the insulin-like substance that resembles insulin and has indeed the same
effects of insulin.

High blood pressure: There is a report about a 67 year old man. He suffered high blood pressure for long time despite taking
medicine to treat it, but was actually cured by eating sakekasu everyday for two months.

3 kinds of peptide were found in sake, while 6 in sakekasu. Experiments with the rats that genetically have high blood pressure
show that, a few days after they are fed with sakekasu, the blood pressure become lower. Also injections of the peptide from
sakekasu into the rats’ body are found as effective as the high blood pressure drug. Of course sakekasu has no medical side

Cerebral infarction: Cerebral infarction is caused by either hardening of cerebral blood vessels or coagulated blood carried
from other parts of body particularly heart. It is triggered by high blood pressure, diabetes, high cholesterol, and sometimes
stress. Sakekasu has an enzyme to help production of urokinase, a substance to activate plasminogen  that resolves
coagulated blood in the blood vessel.

Myocardial infarction (heart attack): Sake reduces heart attack. Research indicates that the group of people who consume sake
has a smaller rate of myocardial infarction (heart attack) and arteriosclerosis, and they live longer.

Pollen allergy as well as regular allergy: An allergic reaction including pollen allergy is basically the immune system gone
haywire. In addition to attacking true enemies such as viruses and bacteria, the immune system of an allergic person also
springs to action when an allergen is present. In response to the presence of the allergen, it attacks with antibodies called
immunoglobulin-E (lgE). Different IgE antibodies are produced by an enzyme called cathepsins-B for each type of allergen,
whether it’s latex, pet dander, oak pollen or ragweed pollen.

Sake, koji and sakekasu include the enzyme called peptide that suppresses chathepsins-B. A frequent eating of sakekasu is
reported to cure the pollen allergy.

Osteoporosis: As one gets older, bones tend to become softer and porous. This is caused by increases of chathepsins-L that
decomposes bones. Researchers at Gekkeikan Research Center discovered that three kinds of peptides that suppress the
effects of chathepsins-L exist in sakekasu. Researchers in University of California as well as those in University of Pittsburgh
have found the sake’s effect to strengthen bones. Three to six cups of alcoholic beverage per week are found to increase
estrogen and prevent osteoporosis of older women.

Benefits known from folk’s experience
Cure from burns and cuts: Workers of sake-breweries use sakekasu as medicine to cure burns and cuts. They bake sakekasu
on a grill over charcoal fire, and then after cooling it is put directly on the cuts or burns. It is known that time of cure is
significantly shorter than any other way.

Freckles remover (the secret of the famous SKII): In every sake brewery, the hands of the chief brewery worker are white and
smooth. The reason is that his hands are often dipped in moromi (fermenting mach) before and during filtration. Freckles are
caused when the dorpacromine, produced by the reaction of chirosinaze and L-chirosin, changes to melamine. On the other
hand, renol acid and albuchine inhibit the reaction of chirosinaze. The renol acid exists in rice and is even abundant in
sakekasu. Thus, sakekasu has the effects of keeping skin whitish and remove freckles.

Cure from Achilles’ tendon injury with sake: A former baseball pitcher, Taniguchi, who used to play in Chunichi Dragons
(professional baseball) team in Japan, suffered from his injury at Achilles’ tendon for a long time. After he retired as a baseball
player, he started a therapy of massage on his Achilles tendon with sake. Not only he recovered thanks to his persistent
practice of massage, he came back as a pitcher and got the title of the top butter.

Chaps and cracks: A popular practice in brewery workers. To cure chaps and cracks, sakekasu is softened with water and rub
over chaps and cracks. The skin not only heals quickly but becomes very smooth.

Sake or sakekasu bathing: Dipping in the hot bath with a cup or two of sake is popular among entertainers in Japan. Sake can
be replaced by sakekasu in the following way. Put a cup of sakekasu in a linen bag and drop in the bath tab. The bag should be
squeezed several times before or during bathing. Rub body surface with the bag. The skin becomes very smooth after bathing,
and stays warm long after.

Benefits of Sake (Rice Wine) &
Sakekasu (Wine Lees or Dregs)
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